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# Cerebellum

The cerebellum is the 'little brain' at the back of the head below the cerebrum; it coordinates movement, balance and timing, and damage makes movement clumsy.

Official name: Anterior quadrangular lobule

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## What it is

The 'little brain' at the back below the cerebrum, with finely folded hemispheres.

## What it does

Coordinates movement, balance and timing; damage makes movements clumsy (ataxia).

## Key points

- Signs are on the same side as the lesion: its output crosses in the [midbrain](https://durgical.com/en/anatomy/midbrain/) and the corticospinal tract crosses back
- Signs: dysmetria (past-pointing), intention tremor, dysdiadochokinesia, nystagmus, scanning speech, hypotonia and a broad-based, unsteady gait
- Three functional parts: vestibulocerebellum (flocculonodular lobe: balance, eye movements), spinocerebellum ([vermis](https://durgical.com/en/anatomy/central-lobule/) and paravermis: trunk and limbs), cerebrocerebellum (lateral hemispheres: planning)
- Purkinje cells are the only output of the cortex and are inhibitory; they act through the deep nuclei: dentate, emboliform, globose, fastigial (lateral to medial)

## Key facts

**Where**
Posterior cranial fossa under the tentorium

**Blood supply**
SCA, AICA, PICA

**Function**
Coordination, balance, motor learning (same side of the body)

## Relations

**Above**
[Tentorium cerebelli](https://durgical.com/en/anatomy/tentorium-cerebelli/), and above it the occipital lobes

**In front**
[Fourth ventricle](https://durgical.com/en/anatomy/fourth-ventricle/), [pons](https://durgical.com/en/anatomy/pons/) and [medulla oblongata](https://durgical.com/en/anatomy/medulla-oblongata/), joined to them by the three [cerebellar peduncles](https://durgical.com/en/anatomy/superior-cerebellar-peduncle/)

**Lateral**
[Sigmoid sinus](https://durgical.com/en/anatomy/sigmoid-sinus/) and the back of the petrous [temporal bone](https://durgical.com/en/anatomy/temporal-bone/); the facial and vestibulocochlear nerves at the cerebellopontine angle

**Behind**
[Occipital bone](https://durgical.com/en/anatomy/occipital-bone/) of the posterior cranial fossa, with the transverse sinuses and the [confluence of sinuses](https://durgical.com/en/anatomy/confluence-of-sinuses/)

**Below**
[Cerebellar tonsils](https://durgical.com/en/anatomy/tonsil-of-cerebellum/) above the [foramen magnum](https://durgical.com/en/anatomy/foramen-magnum/) and the cisterna magna

## How to find it

Fills the posterior fossa below the tentorium, behind the pons and medulla, roofing the fourth ventricle. On the skull its upper limit follows the [transverse sinus](https://durgical.com/en/anatomy/transverse-sinus/) from the inion toward the mastoid (superior nuchal line), the landmark for suboccipital openings. Its tonsils lie beside the medulla above the foramen magnum; a tonsil tip over about 5 mm below it on sagittal MRI suggests Chiari I.

## Examination

- Finger-to-nose: the finger overshoots (dysmetria) and shakes more as it nears the target (intention tremor)
- Heel-to-shin: the heel wavers off the shin; mainly tests the legs and the anterior vermis
- Rapid alternating movements (patting the hand palm up, palm down): slow, irregular rhythm is dysdiadochokinesia
- Tandem gait: falling to one side on heel-to-toe walking; Romberg test is usually negative, as the unsteadiness is present with the eyes open

## On imaging

MRI is the study of choice; on CT the posterior fossa is blurred by streak artefact from the dense skull base. A swollen cerebellar infarct can be seen compressing the fourth ventricle.

## Common problems

- Cerebellar stroke or bleeding: sudden dizziness, vomiting and inability to walk.
- Alcohol and some medicines impair it: unsteady walking, slurred speech.

## How it is diagnosed

Coordination tests (finger-to-nose, heel-to-shin); CT or MRI.

## Treatment

- Treat the cause; surgery to relieve pressure for large strokes or bleeds; balance rehabilitation.

## Clinical notes

- Medulloblastoma, the most common malignant brain tumour in children, arises in the midline cerebellum and can spread through the CSF
- Pilocytic astrocytoma of childhood typically forms a cyst with a nodule in a cerebellar hemisphere; haemangioblastoma is the adult cerebellar tumour linked to von Hippel–Lindau disease
- A large cerebellar infarct or bleed can swell, block the fourth ventricle and compress the brainstem; suboccipital decompression may be lifesaving
- Otogenic cerebellar abscess: middle ear and mastoid infection can spread through the thin posterior surface of the petrous bone or along a thrombosed sigmoid sinus into the adjacent cerebellar hemisphere

## Development

Grows from the dorsal part of the metencephalon (the rhombic lips) and keeps developing after birth. Chiari II and Dandy–Walker malformations are hindbrain anomalies that often come with hydrocephalus.

## Memory aid

Cerebellar signs: DANISH (Dysdiadochokinesia, Ataxia, Nystagmus, Intention tremor, Scanning speech, Hypotonia). Deep nuclei, lateral to medial: 'Don't Eat Greasy Food'.

## Related conditions

- [Maple syrup urine disease](https://durgical.com/en/conditions/maple-syrup-urine-disease/)
- [Congenital disorder of glycosylation type Ia (PMM2-CDG)](https://durgical.com/en/conditions/congenital-disorder-of-glycosylation-type-ia/)
- [Sandhoff disease](https://durgical.com/en/conditions/sandhoff-disease/)
- [Ataxia-telangiectasia](https://durgical.com/en/conditions/ataxia-telangiectasia/)
- [Prion diseases (Creutzfeldt–Jakob)](https://durgical.com/en/conditions/prion-diseases/)
- [Mercury poisoning](https://durgical.com/en/conditions/mercury-poisoning/)
- [Menkes disease](https://durgical.com/en/conditions/menkes-disease/)
- [Intracerebral haemorrhage](https://durgical.com/en/conditions/intracerebral-haemorrhage/)
- [Acute alcohol (ethanol) intoxication](https://durgical.com/en/conditions/acute-alcohol-intoxication/)
- [Anticonvulsant toxicity (phenytoin, carbamazepine, valproate)](https://durgical.com/en/conditions/anticonvulsant-toxicity/)
- [Rabies](https://durgical.com/en/conditions/rabies/)
- [Essential tremor](https://durgical.com/en/conditions/essential-tremor/)
- [Brain metastases](https://durgical.com/en/conditions/brain-metastases/)
- [Childhood brain tumours (medulloblastoma, pilocytic astrocytoma, craniopharyngioma)](https://durgical.com/en/conditions/childhood-brain-tumours/)
- [Friedreich ataxia](https://durgical.com/en/conditions/friedreich-ataxia/)
- [Multiple system atrophy (MSA)](https://durgical.com/en/conditions/multiple-system-atrophy/)
- [Spinocerebellar ataxias (autosomal dominant ataxias)](https://durgical.com/en/conditions/spinocerebellar-ataxias/)
- [Alcohol use disorder](https://durgical.com/en/conditions/alcohol-use-disorder/)
- [Autism spectrum disorder (ASD)](https://durgical.com/en/conditions/autism-spectrum-disorder/)
- [Cannabis use disorder](https://durgical.com/en/conditions/cannabis-use-disorder/)
- [Lithium toxicity](https://durgical.com/en/conditions/lithium-toxicity/)

## Test yourself

Think of the answer, then tap the question to see it.

## On which side of the body do cerebellar signs appear?

On the same side as the lesion, because its output crosses in the midbrain and the corticospinal tract crosses back.

## What are the classic cerebellar signs?

Dysmetria, intention tremor, dysdiadochokinesia, nystagmus, scanning speech, hypotonia and a broad-based unsteady gait.

## What does the finger-to-nose test show in cerebellar disease?

The finger overshoots (dysmetria) and shakes more as it nears the target (intention tremor).

## Why is the Romberg test usually negative in cerebellar ataxia?

The unsteadiness is present with the eyes open too, so closing them adds little.

## Which is the most common malignant brain tumour in children, and where does it arise?

Medulloblastoma, in the midline cerebellum; it can spread through the CSF.

[Add to my cards (5)](https://durgical.app/estudiar/?add=/en/anatomy/anterior-quadrangular-lobule/)

Educational information, not medical advice. For any symptom, see a health professional.

## Its names

**Official Latin (TA2)**
lobulus quadrangularis anterior TA2 5808

**Official Spanish (DeCS)**
Cerebelo DeCS D002531

**English (TA2)**
Anterior quadrangular lobule

## Related

- [Fourth ventricle](https://durgical.com/en/anatomy/fourth-ventricle/)
- [Cerebellar arteries](https://durgical.com/en/anatomy/superior-cerebellar-artery/)

Sources: Terminologia Anatomica (TA2); [DeCS](https://decs.bvsalud.org/es/ths/resource/?id=2568); [Neuroanatomy, Cerebellum](https://www.ncbi.nlm.nih.gov/books/NBK538167/); [13.1 The Embryologic Perspective](https://openstax.org/books/anatomy-and-physiology-2e/pages/13-1-the-embryologic-perspective) (OpenStax (Rice University), 2022) · adapted, [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/); [13.2 The Central Nervous System](https://openstax.org/books/anatomy-and-physiology-2e/pages/13-2-the-central-nervous-system) (OpenStax (Rice University), 2022) · adapted, [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/); Tratado de anatomía humana (9.ª ed.), tomo II, Libro V, sección 2 (Encéfalo), capítulos I-V: bulbo, protuberancia, cerebelo, cuarto ventrículo, mesencéfalo.

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Representative model, for educational purposes only.

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Source: https://durgical.com/en/anatomy/anterior-quadrangular-lobule/
License: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Cite as: DurgiPedia (durgical.com), https://durgical.com/en/anatomy/anterior-quadrangular-lobule/
