[Durgical](https://durgical.com/en/) › [DurgiPedia](https://durgical.com/en/durgipedia/) › [Pharmacology](https://durgical.com/en/pharmacology/) › [Hereditary angioedema agents](https://durgical.com/en/pharmacology/classes/hereditary-angioedema-agents/) › Lanadelumab

# Lanadelumab

## Hereditary angioedema agents?

Hereditary angioedema agents

A human antibody that blocks plasma kallikrein; injected under the skin at intervals, it prevents hereditary angioedema attacks.

Updated Nov 1, 2026

Also called: lanadelumab-flyo

## Quick facts

**Group**
[Hereditary angioedema agents](https://durgical.com/en/pharmacology/classes/hereditary-angioedema-agents/)

**Target**
Plasma kallikrein

**Key effects**
Injection-site pain · Headache · Muscle pain

**Monitor**
Attack diary to judge prevention

**ATC**
B06AC05

No doses: the clinician sets them by the current guideline.

On this page

- The basics Mechanism of action
- Indications
- Adverse effects
- Pharmacokinetics
- Memory aid

- Safety Contraindications
- Key interactions
- What is monitored
- Administration and safety
- Pregnancy and breastfeeding
- Nursing care

- Study Test yourself

- Connections Connections

## Mechanism of action

✂**Plasma kallikrein**Lanadelumab

ⓘ The figure shows human plasma kallikrein with the binding fragment (Fab) of DX-2930, the development code of lanadelumab, covering the active site; as an antibody it has no small-molecule ligand.

**Target in 3D:** Plasma kallikrein. PDB structure 4OGY (RCSB PDB, public domain). [View the structure at RCSB PDB](https://www.rcsb.org/structure/4OGY) · Drag to rotate · pinch to zoom

Lanadelumab is a fully human IgG1 monoclonal antibody that binds active plasma kallikrein and blocks its active site. The enzyme can no longer cut high-molecular-weight kininogen, so less bradykinin is produced and attacks become rarer.

- Lanadelumab binds active plasma kallikrein
- Kallikrein cannot cleave high-molecular-weight kininogen
- Less bradykinin is released and fewer attacks occur

## Indications

- Prevention of hereditary angioedema attacks (adults and children from 2 years) [Urticaria and angioedema →](https://durgical.com/en/conditions/urticaria-and-angioedema/)

## Adverse effects

### Common

- Injection-site pain, bruising or redness
- Headache, dizziness
- Muscle pain
- Diarrhoea
- Cold-like symptoms (cough, runny nose, sore throat)

### Serious (rare, important)

- Allergic reactions (rash, hives, swelling of face or throat, breathing difficulty), which are rare

## Contraindications

- Hypersensitivity to lanadelumab

## Key interactions

**Other medicines**
No specific interactions are listed; acute-attack treatment is still kept at hand

## What is monitored

- Attack diary to judge prevention
- Allergic reactions after injections

## Administration and safety

- Subcutaneous injection into the thigh or abdomen, avoiding the navel, sites rotated; home injection after training
- Brought to room temperature without heating; not shaken; not used if cloudy or with particles
- Stored refrigerated, protected from light, never frozen
- It does not treat an acute attack

## Pregnancy and breastfeeding

Pregnancy, plans for pregnancy or breastfeeding are discussed with the treating team before use.

## Nursing care

- Teach injection technique and sharps disposal
- Make sure the patient still has an acute-attack plan
- Teach signs of allergy that need urgent care
- Remind not to stop without speaking to the doctor

## Pharmacokinetics

**Absorption**
Subcutaneous injection

**Elimination**
Broken down like other antibodies; long-acting, so doses are spaced

## Memory aid

«LANA keeps the kallikrein locked»: a long-acting antibody that prevents, not treats.

## Test yourself

Think of the answer, then tap the question to see it.

## What does lanadelumab bind?

Active plasma kallikrein.

## Does it treat acute attacks?

No, it prevents attacks.

## Which oral drug shares its target?

Berotralstat.

[Add to my cards (3)](https://durgical.app/estudiar/?add=/en/pharmacology/lanadelumab/)

[More Pharmacology questions →](https://durgical.com/en/practice/?f=pharmacology)

## Connections

## Related drugs 3

- [Berotralstat](https://durgical.com/en/pharmacology/berotralstat/)
- [C1 esterase inhibitor](https://durgical.com/en/pharmacology/c1-esterase-inhibitor/)
- [Icatibant](https://durgical.com/en/pharmacology/icatibant/)

## Related conditions 1

- [Urticaria and angioedema](https://durgical.com/en/conditions/urticaria-and-angioedema/)

[← Back to the class: Hereditary angioedema agents](https://durgical.com/en/pharmacology/classes/hereditary-angioedema-agents/)

Educational content on how drugs work; not a prescribing guide and no substitute for a health professional's advice. No doses are given.

Sources: [Lanadelumab-flyo injection: MedlinePlus Drug Information](https://medlineplus.gov/druginfo/meds/a622035.html) (MedlinePlus (U.S. National Library of Medicine), 2025); [4OGY: Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution](https://www.rcsb.org/structure/4OGY) (RCSB Protein Data Bank, 2014).

## **Spotted a mistake?** We are always improving for the community. Tell us what is wrong and our team will review it. Report a mistake

Representative model, for educational purposes only.

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Source: https://durgical.com/en/pharmacology/lanadelumab/
License: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Cite as: DurgiPedia (durgical.com), https://durgical.com/en/pharmacology/lanadelumab/