[Durgical](https://durgical.com/en/) › [DurgiPedia](https://durgical.com/en/durgipedia/) › [Pharmacology](https://durgical.com/en/pharmacology/) › [Wake-promoting agents and narcolepsy drugs](https://durgical.com/en/pharmacology/classes/wake-promoting-agents-and-narcolepsy-drugs/) › Solriamfetol

# Solriamfetol

## Wake-promoting agents and narcolepsy drugs?

Wake-promoting agents and narcolepsy drugs

A wake-promoting drug for daytime sleepiness in narcolepsy or obstructive sleep apnoea. It blocks noradrenaline reuptake and can raise blood pressure.

Updated Nov 1, 2026

## Quick facts

**Group**
[Wake-promoting agents and narcolepsy drugs](https://durgical.com/en/pharmacology/classes/wake-promoting-agents-and-narcolepsy-drugs/)

**Target**
Noradrenaline transporter (NET)

**Used for**
Excessive daytime sleepiness

**Key effects**
Headache · Nausea and less appetite · Insomnia

**Monitor**
Blood pressure and heart rate before

**ATC**
N06BA14

No doses: the clinician sets them by the current guideline.

On this page

- The basics Mechanism of action
- Indications
- Adverse effects
- Pharmacokinetics
- Memory aid

- Safety Contraindications
- Key interactions
- What is monitored
- Administration and safety
- Nursing care

- Study Test yourself

- Connections Connections

## Mechanism of action

Solriamfetol inhibits the noradrenaline transporter (NET), so noradrenaline stays longer in the synapse and wake-promoting signalling increases. The same effect on the sympathetic system explains the rise in blood pressure and heart rate.

- Inhibits the noradrenaline transporter (NET)
- Synaptic noradrenaline rises
- More wakefulness; blood pressure and pulse may rise

## Indications

- Excessive daytime sleepiness in narcolepsy [Narcolepsy →](https://durgical.com/en/conditions/narcolepsy/)
- Excessive daytime sleepiness in obstructive sleep apnoea, with airway treatment [Obstructive sleep apnoea →](https://durgical.com/en/conditions/obstructive-sleep-apnoea/)

## Adverse effects

### Common

- Headache
- Nausea and less appetite
- Insomnia
- Anxiety

### Serious (rare, important)

- Higher blood pressure and heart rate, with risk in heart disease
- Agitation, mania or hallucinations

## Contraindications

- Use of an MAO inhibitor now or in the last two weeks

## Key interactions

**MAO inhibitors**
Avoided together or within two weeks of stopping one

**Other drugs that raise blood pressure or heart rate**
Added cardiovascular effect

## What is monitored

- Blood pressure and heart rate before and during treatment
- Mood and signs of misuse

## Administration and safety

- Given by mouth once a day at the same time
- It may be habit-forming; signs of misuse are watched

## Nursing care

- Measure blood pressure and pulse before starting and at follow-up
- Ask about heart disease, kidney disease and psychiatric history
- Remind that it does not replace CPAP in sleep apnoea

## Pharmacokinetics

**Elimination**
Kidney function matters: kidney disease is reviewed before starting

## Memory aid

Solriamfetol: «block the NET, stay awake» – noradrenaline reuptake block; check the blood pressure.

## Test yourself

Think of the answer, then tap the question to see it.

## Which transporter does solriamfetol block?

The noradrenaline transporter (NET).

## Which vital signs are checked on solriamfetol?

Blood pressure and heart rate.

## Which drug class must not be combined with it?

MAO inhibitors, now or in the previous two weeks.

[Add to my cards (3)](https://durgical.app/estudiar/?add=/en/pharmacology/solriamfetol/)

[More Pharmacology questions →](https://durgical.com/en/practice/?f=pharmacology)

## Connections

## Related drugs 4

- [Modafinil](https://durgical.com/en/pharmacology/modafinil/)
- [Armodafinil](https://durgical.com/en/pharmacology/armodafinil/)
- [Pitolisant](https://durgical.com/en/pharmacology/pitolisant/)
- [Atomoxetine](https://durgical.com/en/pharmacology/atomoxetine/)

## Related conditions 2

- [Narcolepsy](https://durgical.com/en/conditions/narcolepsy/)
- [Obstructive sleep apnoea](https://durgical.com/en/conditions/obstructive-sleep-apnoea/)

[← Back to the class: Wake-promoting agents and narcolepsy drugs](https://durgical.com/en/pharmacology/classes/wake-promoting-agents-and-narcolepsy-drugs/)

Educational content on how drugs work; not a prescribing guide and no substitute for a health professional's advice. No doses are given.

Sources: [Solriamfetol: MedlinePlus Drug Information](https://medlineplus.gov/druginfo/meds/a619040.html) (MedlinePlus (U.S. National Library of Medicine), 2026); [ATCDDD - ATC/DDD Index](https://atcddd.fhi.no/atc_ddd_index/?code=N06BA14) (WHO Collaborating Centre for Drug Statistics Methodology, 2026).

## **Spotted a mistake?** We are always improving for the community. Tell us what is wrong and our team will review it. Report a mistake

Representative model, for educational purposes only.

---
Source: https://durgical.com/en/pharmacology/solriamfetol/
License: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Cite as: DurgiPedia (durgical.com), https://durgical.com/en/pharmacology/solriamfetol/