[Durgical](https://durgical.com/en/) › [DurgiPedia](https://durgical.com/en/durgipedia/) › [Pharmacology](https://durgical.com/en/pharmacology/) › [CGRP antagonists (gepants and anti-CGRP antibodies)](https://durgical.com/en/pharmacology/classes/cgrp-antagonists/) › Ubrogepant

# Ubrogepant

## CGRP antagonists (gepants and anti-CGRP antibodies)?

CGRP antagonists (gepants and anti-CGRP antibodies)

An oral CGRP receptor blocker for migraine attacks. It does not prevent migraine or reduce the number of headaches.

Updated Nov 1, 2026

## Quick facts

**Group**
[CGRP antagonists (gepants and anti-CGRP antibodies)](https://durgical.com/en/pharmacology/classes/cgrp-antagonists/)

**Target**
CGRP receptor (calcitonin receptor-like receptor, CALCRL, with RAMP1)

**Used for**
Acute treatment of migraine attacks

**Key effects**
Nausea · Drowsiness · Dry mouth

**Monitor**
Headache diary · Blood pressure

**ATC**
N02CD04

No doses: the clinician sets them by the current guideline.

On this page

- The basics Mechanism of action
- Indications
- Adverse effects
- Pharmacokinetics
- Memory aid

- Safety Contraindications
- Key interactions
- What is monitored
- Administration and safety
- Pregnancy and breastfeeding
- Nursing care

- Study Test yourself

- Connections Connections

## Mechanism of action

◎**CGRP receptor (calcitonin receptor-like receptor, CALCRL, with RAMP1)**Ubrogepant

ⓘ The figure shows telcagepant, an earlier gepant that was never marketed, bound to the extracellular domains of the human CGRP receptor (CLR with RAMP1), where small-molecule gepants block the receptor; there is no structure with this drug.

**Target in 3D:** CGRP receptor (calcitonin receptor-like receptor, CALCRL, with RAMP1). PDB structure 3N7R (RCSB PDB, public domain). [View the structure at RCSB PDB](https://www.rcsb.org/structure/3N7R) · Drag to rotate · pinch to zoom

Ubrogepant is a small-molecule antagonist of the CGRP receptor (a gepant). Calcitonin gene-related peptide (CGRP), released by trigeminal nerves during migraine, dilates meningeal vessels and drives neurogenic inflammation. Gepants bind at the junction of the two receptor subunits (CLR and RAMP1) and stop CGRP from activating it. Unlike triptans, they do not constrict blood vessels.

- Ubrogepant binds the CGRP receptor
- Trigeminal CGRP can no longer act
- Less vasodilation and neurogenic inflammation
- The attack eases

## Indications

- Acute treatment of migraine attacks in adults [Migraine →](https://durgical.com/en/conditions/migraine/)

## Adverse effects

### Common

- Nausea
- Drowsiness
- Dry mouth

### Serious (rare, important)

- Allergic reactions: swelling of the face or throat, hives, trouble breathing
- Raynaud phenomenon: numb, cold, painful or discoloured fingers or toes

## Contraindications

- Hypersensitivity to ubrogepant or any component of the product

## Key interactions

**St John's wort and curcumin**
May interact with ubrogepant; they are reviewed before starting

**Grapefruit and grapefruit juice**
A second tablet within 24 hours is avoided

**Some other medicines**
The treating team may advise against a second tablet within 24 hours

## What is monitored

- Headache diary: attacks treated per month
- Blood pressure
- Headaches that become more frequent

## Administration and safety

- Oral tablet at the first sign of migraine; a second dose may be allowed after some hours if prescribed
- The maximum number of tablets per day and of attacks treated per month is set by the treating team

## Pregnancy and breastfeeding

There is little information in pregnancy; it is a decision for the treating team.

## Nursing care

- Ask about hypertension, Raynaud phenomenon, kidney and liver disease
- Review supplements, including St John's wort and curcumin
- Teach to report headaches that do not improve or become more frequent

## Pharmacokinetics

**Absorption**
Oral tablet taken at the first sign of an attack

## Memory aid

«UBROgepant = U BReak the attack Only»: acute use, no prevention.

## Test yourself

Think of the answer, then tap the question to see it.

## Does ubrogepant prevent migraine?

No; it only treats attacks.

## Which supplements may interact with ubrogepant?

St John's wort and curcumin.

## What is the drug class of ubrogepant?

Gepants: small-molecule CGRP receptor antagonists.

[Add to my cards (3)](https://durgical.app/estudiar/?add=/en/pharmacology/ubrogepant/)

[More Pharmacology questions →](https://durgical.com/en/practice/?f=pharmacology)

## Connections

## Related drugs 4

- [Rimegepant](https://durgical.com/en/pharmacology/rimegepant/)
- [Atogepant](https://durgical.com/en/pharmacology/atogepant/)
- [Lasmiditan](https://durgical.com/en/pharmacology/lasmiditan/)
- [Sumatriptan](https://durgical.com/en/pharmacology/sumatriptan/)

## Related conditions 1

- [Migraine](https://durgical.com/en/conditions/migraine/)

[← Back to the class: CGRP antagonists (gepants and anti-CGRP antibodies)](https://durgical.com/en/pharmacology/classes/cgrp-antagonists/)

Educational content on how drugs work; not a prescribing guide and no substitute for a health professional's advice. No doses are given.

Sources: [Ubrogepant: MedlinePlus Drug Information](https://medlineplus.gov/druginfo/meds/a620016.html) (MedlinePlus (U.S. National Library of Medicine), 2026); [ATCDDD - ATC/DDD Index](https://atcddd.fhi.no/atc_ddd_index/?code=N02CD04) (WHO Collaborating Centre for Drug Statistics Methodology, 2026); [RCSB PDB - 3N7R: Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism](https://www.rcsb.org/structure/3N7R) (RCSB Protein Data Bank, 2026).

## **Spotted a mistake?** We are always improving for the community. Tell us what is wrong and our team will review it. Report a mistake

Representative model, for educational purposes only.

---
Source: https://durgical.com/en/pharmacology/ubrogepant/
License: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Cite as: DurgiPedia (durgical.com), https://durgical.com/en/pharmacology/ubrogepant/