Single-gene inheritance

Mendelian patterns, pedigrees and the exceptions to the rules.

6 pages

• Mendelian inheritance: autosomal dominant, recessive and X-linkedWhen a disease depends on a single gene, it passes through families in predictable patterns that…
• Inheritance concepts, genotype–phenotype and the pedigreeThe words geneticists use to link a genotype to what a person shows, and how a three-generation…
• How a single gene causes disease: enzymes, receptors and structural proteinsAn altered gene makes a protein that is missing, works badly or gets in the way; the kind of…
• Nonclassic inheritance: repeat expansions, mitochondrial genes, imprinting, mosaicismSome genetic diseases break Mendel's rules: they worsen from one generation to the next, pass…
• Mitochondrial inheritance and mitochondrial DNA diseaseMitochondria carry their own small genome, passed only from the mother; how much faulty mtDNA a…
• Genomic imprinting: Prader–Willi and AngelmanSome genes work only when they come from the father and others only from the mother; losing the…

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This section is an index: it gathers pages from Biochemistry, Pathology, Embryology and other sections without repeating them. Educational content; it does not replace a geneticist's assessment or genetic counselling.

Representative model, for educational purposes only.