Biochemistry · Molecule
Fructose 1,6-bisphosphate !
Fructose 1,6-bisphosphate is the two-phosphate sugar made by the committed step of glycolysis; aldolase splits it in two.
Updated 2026-10-31
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Key facts
- Phosphofructokinase-1 makes it (step 3) using ATP; aldolase splits it into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
- It activates pyruvate kinase ahead of time: what comes in at the top speeds the exit at the bottom.
- In gluconeogenesis, fructose-1,6-bisphosphatase turns it back into fructose 6-phosphate; fructose 2,6-bisphosphate and AMP inhibit it.
- Also called
- F1,6BP
- Formula
- C₆H₁₄O₁₂P₂
- PubChem
- CID 10267
Structure
- A furanose ring (five atoms) with phosphates on carbons 1 and 6; not to be confused with fructose 2,6-bisphosphate, which only regulates.
Clinical notes
- Fructose-1,6-bisphosphatase deficiency causes fasting hypoglycemia and lactic acidosis, because it blocks gluconeogenesis.
Pathways
Related conditions
Related
Test yourself
Think of the answer, then tap the question to see it.
Which enzyme splits fructose 1,6-bisphosphate?
Aldolase, into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
Which enzyme does fructose 1,6-bisphosphate activate ahead of time?
Pyruvate kinase (step 10).
How does it differ from fructose 2,6-bisphosphate?
The 1,6 form is a glycolysis intermediate; the 2,6 form is not metabolised: it only activates PFK-1 and inhibits fructose-1,6-bisphosphatase.
Molecules are shown in their neutral form, as the databases deposit them; in the cell the acids and phosphates are ionised.
Educational information, not medical advice. For any symptom, see a health professional.
Sources: beta-D-Fructose 1,6-bisphosphate (CID 10267) (PubChem, NCBI, 2026) · Public domain; Glycolysis (Reactome, 2026); Textbook of Biochemistry for Medical Students, 6th ed. (Jaypee Brothers Medical Publishers (Vasudevan DM, Sreekumari S, Vaidyanathan K), 2011).
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