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Pharmacology · Oxazolidinones

Tedizolid !

A once-daily oxazolidinone, oral or IV, for gram-positive skin infections including MRSA; similar to linezolid.

Updated 2026-11-01

  • Class: Oxazolidinones
  • Target: Peptidyl-transferase centre of the 23S rRNA, 50S ribosomal subunit
  • ATC code: J01XX11

The figure shows tedizolid in the 50S ribosomal subunit of methicillin-resistant Staphylococcus aureus.

Target in 3D: Peptidyl-transferase centre of the 23S rRNA, 50S ribosomal subunit. PDB structure 6WRS (RCSB PDB, public domain). View the structure at RCSB PDB

Mechanism of action

Tedizolid binds the 23S rRNA of the 50S subunit, like linezolid, and stops bacterial protein synthesis, which halts growth. Its spectrum is similar to linezolid's: staphylococci (including MRSA), streptococci and enterococci.

  1. Binds the 23S rRNA of the 50S subunit
  2. Bacterial protein synthesis stops
  3. Gram-positive growth stops

Pharmacokinetics

Absorption
Tablets or IV infusion, once a day; it can be taken with or without food.
Metabolism
Not a substrate or inhibitor of cytochrome P450 enzymes.

Indications

Adverse effects

Common

  • Nausea, vomiting, diarrhoea, headache

Contraindications

  • Hypersensitivity to tedizolid

Key interactions

SSRIs and other serotonergic drugs
Possible serotonin syndrome, though preclinical data suggest a lower risk than with linezolid.

What is monitored

  • Blood count in patients with prior low white cells
  • Signs of serotonin syndrome with serotonergic drugs

Administration and safety

  • Oral and IV doses are given once daily at about the same time.
  • The full short course is completed even if the skin improves.

Nursing care

  • Review antidepressants and other serotonergic drugs before the first dose.
  • Ask about previous low white blood cell counts.
  • Teaching: report fever, sweating, agitation, tremor or diarrhoea.

Pregnancy and breastfeeding

Human data are limited; the pregnancy is reported to the treating team, which weighs benefit and risk.

Test yourself

Think of the answer, then tap the question to see it.

What does tedizolid share with linezolid?

The target (23S rRNA of the 50S subunit) and a similar gram-positive spectrum, including MRSA.

Which interaction is still watched for with tedizolid?

Serotonin syndrome with serotonergic drugs such as SSRIs.

Is tedizolid metabolized by cytochrome P450?

No; it is neither a substrate nor an inhibitor of CYP enzymes.

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← Back to the class: Oxazolidinones

Educational content on how drugs work; not a prescribing guide and no substitute for a health professional's advice. No doses are given.

Sources: Tedizolid: MedlinePlus Drug Information (MedlinePlus (U.S. National Library of Medicine), 2026); Goodman & Gilman's The Pharmacological Basis of Therapeutics, 14th ed., ch. 60 (McGraw Hill, 2023); RCSB PDB - 6WRS: Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, tedizolid (RCSB Protein Data Bank, 2026).

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Representative model, for educational purposes only.