Pseudogout (CPPD) of the Knee !
Pseudogout of the knee is joint inflammation caused by calcium pyrophosphate crystals; the knee is the joint it affects most often.
Updated 2026-10-23
Structures involved
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In the clinical exam
Why it happens
- Pathologic calcification: dystrophic vs metastatic
- Cartilage: hyaline, elastic, fibrocartilage
- Synovial joints: capsule, synovial membrane and articular cartilage
What it is
Calcium pyrophosphate crystal deposition disease. The knee is its most common joint.
Symptoms and signs
- Acute monoarthritis similar to gout
- May be chronic
Diagnosis
- Clinical
- Acute monoarthritis
- Tests
- Joint fluid showing positively birefringent rhomboid crystals
- Imaging
- Chondrocalcinosis on X-ray
Treatment
- Acute
- Anti-inflammatory treatment.
Related conditions
Educational information, not medical advice. For any symptom, see a health professional.
Sources: Calcium Pyrophosphate Deposition Disease (StatPearls (NCBI Bookshelf), 2024).
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Representative model, for educational purposes only.
